关于工程项目建设规划决策的优化

本主要介绍以工程项目动态回收期最短为目标的建设规模优化模型,提出了辅助决策的三个综合评价投资效益的指标,并简要介绍应用情况。     

The Solution Construction of Heterotic Super-Liouville Model

We investigate the heterotic super-Liouville model on the base of the basic Lie super-algebra Osp(1|2).Using the super extension of Leznov-Saveliev analysis and Drinfeld Sokolov linear system, we construct the explicit solution of the heterotic super-Liouville system in component form. We also show that the solutions are local and periodic by calculating the exchange relation of the solution. Finally starting from the action of heterotic super-Liou ville model, we obtain the conserved current and conserved charge which possessed the BR ST properties.     

DREAM++: Flexible docking program for virtual combinatorial libraries

We present a set of programs, DREAM++ (Docking and Reaction programs using Efficient seArch Methods written in C++), for docking computationally generated ligands into macromolecular binding sites. DREAM++ is composed of three programs: ORIENT++, REACT++ and SEARCH++. The program ORIENT++ positions molecules in a binding site with the DOCK algorithm [1, 2]. Its output can be used as input to REACT++ and SEARCH++. The program REACT++ performs user-specified chemical reactions on a docked molecule, so that reaction products can be evaluated for three dimensional complementarity with the macromolecular site. The program SEARCH++ performs an efficient conformation search on the reaction products using a hybrid backtrack [3, 4] and incremental construction [5, 6] algorithm. We have applied the programs to HIV protease–inhibitor complexes as test systems. We found that we can differentiate high-affinity ligands based on several measures: interaction energies, occupancy of protein subsites and the number of successfully docked conformations for each product. Encouraged by the results in the test case, we applied the programs to propose novel inhibitors of HIV protease. These inhibitors can be generated by organic reactions using commercially available reagents. They are alternatives to the inhibitors synthesized by Glaxo [7, 8].     

钢筋混凝土盾构衬砌结构的三维数值分析

结合地铁盾构隧道工程实例,应用三维有限元模型和ANSYS程序分析了上部和周围土体荷载作用下钢筋混凝土衬砌的应力、应变分布与开裂规律。模型考虑了衬砌与周围土体的共同作用、土体和钢筋混凝土材料的弹塑性性质,通过刚度折减考虑了管片接头不连续性对衬砌应力、应变与开裂性质的影响。     

南开大学分析化学学科的建设与发展

2021年正值南开大学化学学科创建100周年。作为南开化学的一个重要分支,南开大学分析化学学科始建于1952年。回顾了南开分析学科的历史脉络和发展成就;着重介绍了南开分析学科的发展现状;面向国家重大需求,提出了学科的未来发展方向。谨以此文,敬献给为南开分析学科发展做出贡献的南开人及支持、帮助本学科发展的朋友们！向南开大学化学学科创建100周年致敬！     

一流课程建设——基础化学实验

从教学团队、课程内容、教学模式、教学条件及考核模式等方面的改革介绍了基础化学实验一流课程建设,即以开展实验教学培训、鼓励交流合作、打破编制壁垒建设实验教学团队;以科研反哺教学、开展实验竞赛、注重教材建设改革课程内容;以“讲一练二考三”“简易混合式”“思想实验”等创新教学模式培养学生创新能力;以更新仪器设备及运用信息技术改进教学条件;并通过评教机制及魅力化学实验课堂机制改革基础实验考核模式。     

初中阶段质量概念的建构

质量是建构学生物质观的一个重要概念,在初中阶段学生原有的认知结构中,质量概念是依据生活经验建立的,其本质只是"重量"的概念.设计了一个依托问题情境的教学环境,在历史发展的背景下,以问题链的形式引导学生建构质量概念,并为高中阶段进一步建构质量概念做好铺垫和支撑.     

Constructions for near resolvable designs and BIBDs

The purpose of this article is twofold. First, it is shown that classical inversive planes of even order can be used to construct a class of 2—(2²ⁿ + 1, 2ⁿ, 2ⁿ—1) near resolvable designs, in which any two blocks have at most 2 points in common. Secondly, it is shown that a recursive construction method for BIBDs using resolvable BIBDs due to Shrikhande and Raghavarao can be extended by using near resolvable designs. © 1999 John Wiley & Sons, Inc. J Combin Designs 7: 227–231, 1999     

Functional Nanomaterial-Modified Anodes in Microbial Fuel Cells: Advances and Perspectives

Microbial fuel cell (MFC) is a promising approach that could utilize microorganisms to oxidize biodegradable pollutants in wastewater and generate electrical power simultaneously. Introducing advanced anode nanomaterials is generally considered as an effective way to enhance MFC performance by increasing bacterial adhesion and facilitating extracellular electron transfer (EET). This review focuses on the key advances of recent anode modification materials, as well as the current understanding of the microbial EET process occurring at the bacteria-electrode interface. Based on the difference in combination mode of the exoelectrogens and nanomaterials, anode surface modification, hybrid biofilm construction and single-bacterial surface modification strategies are elucidated exhaustively. The inherent mechanisms may help to break through the performance output bottleneck of MFCs by rational design of EET-related nanomaterials, and lead to the widespread application of microbial electrochemical systems.     

双缆悬索桥空缆状态主缆抗滑安全性研究

为指导双缆悬索桥上下缆垂跨比的取值，明确双缆悬索桥施工阶段主缆抗滑稳定性，提出一种主缆在施工阶段空缆状态下的抗滑安全系数计算方法。基于上缆变下缆的主缆布置方式，通过双缆悬索桥成桥状态反推空缆状态主缆垂度，根据空缆状态下主缆线形为悬链线计算中塔塔顶鞍座处缆力及包角，并据此计算空缆状态抗滑安全系数。建立多塔悬索桥有限元模型对提出的公式进行验证，分析成桥状态上下缆垂跨比和桥梁跨度的取值对空缆到成桥状态主缆垂度变化以及抗滑安全系数的影响。结果表明，采用本文公式计算的双缆悬索桥空缆状态下抗滑安全系数精度较高；上下缆垂跨比对空缆状态主缆抗滑安全性影响较大，抗滑安全系数随着上下缆垂跨比差值的增大迅速减小；空缆状态主缆抗滑安全系数受跨度影响不大，其随跨度增大略有提高。在实际的双缆悬索桥初步设计过程中应考虑施工阶段主缆抗滑稳定性，选择适宜的上下缆垂跨比，采取措施提高施工阶段主缆抗滑安全性。